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Some users report minor digestive changes, particularly with higher doses

In addition, we have shown that 1 month of r-hGH treatment is associated with changes in the expression of a large set of genes involved in regulating processes such as the cell cycle, cellular movement and function and carbohydrate metabolism

& Lozano, A

However, given the associated risks of cardiovascular disease and various cancers, the benefits of these medications, such as better glycemic control, weight loss and improvement in cardiometabolic risk factors as well as other obesity complications, appear to outweigh the risks for most adults with obesity [143, 153]